WHAT IS SORGHUM BICOLOR
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Sorghum bicolor is a species of grass, traditionally cultivated for its nutritious grain. Sorghum is now grown in many tropical and subtropical regions of the world and is gaining increased popularity as a non-gluten grain. Historical uses of Sorghum include food, hot teas, beers, and traditional medicinal extracts.
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Health Benefits Include
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Multi-facetted anti-inflammatory properties
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Immune activation
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Hematopoietic effect
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Pain reduction
ANTI-INFLAMMATORY
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AFRICAN SORGHUM-BASED JOBELYN® HAS ANTI-INFLAMMATORY PROPERTIES
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Jobelyn® is produced from a unique wild variety of Sorghum bicolor, recently domesticated from a West African wild variety, representing original genetic makeup and not a result of intense breeding efforts. Jobelyn® is an extract derived specifically from the intensely colored leaf sheaths. Sorghum is GRAS-certified by the FDA. Jobelyn® has an unusual chemical profile compared to other variants of Sorghum bicolor. It has a very high content of unique antioxidant polyphenols, including unique dimeric 3-deoxyanthocyanidins. These compounds contribute to the chemical and biological antioxidant effects.
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Chronic inflammatory conditions underlie many aspects of declining physical and mental health. Comprehensive anti-inflammatory nutritional strategies are increasingly gaining attention for health management.
Inflammation involves multiple pathways, including:
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Production of damaging free radicals
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Infiltration of inflammatory cells into target tissues
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Up-regulation of inflammatory enzymes, such as COX-2
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Jobelyn® was evaluated in laboratory tests involving separate mechanisms of action. Jobelyn® contains a complex array of compounds with different chemical properties that inhibit free radical production, reduce infiltration of inflammatory cells, and inhibit COX-2 enzymatic activity. This suggests a multi-faceted anti-inflammatory capacity of JobelynTM
ANTI-OXIDANT
ANTIOXIDANT CAPACITY AND CELLULAR PROTECTION BY THE WEST AFRICAN SORGHUM-BASED PRODUCT – JOBELYN®
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Oxygen is essential for our life. However, oxygen is used in chemical reactions in our body to produce free radicals, which are harmful, electrically charged ions. Antioxidants are compounds capable of neutralizing free radicals that would otherwise potentially damage cells and tissues. Antioxidants help to prevent damage to cells and tissue, and provide multi-faceted health benefits.
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There are different methods to test for antioxidants. Each method provides different information. For this reason, a sequential testing strategy was used.
The Oxygen Radical Absorbance Capacity or `ORAC’ test, is a widely used antioxidant test. It measures chemical antioxidant capacity, and was used to test Jobelyn®.
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DEFINITIONS
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Free radical:
An atom or group of atoms with at least one unpaired electron. Unpaired electrons are highly reactive and can damage living cells.
Antioxidant:
A compound capable of donating an electron and thus neutralizing the electrical charge that may otherwise lead to cascading cellular damage.
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While the ORAC test helps demonstrate whether a product contains chemicals that are able to perform antioxidant reactions, it does not tell us if compounds are functioning as protective antioxidants in biological systems. Because of this limitation of the ORAC test, the Cellular Antioxidant Protection in erythrocytes, or CAP-e, test was also used to test Jobelyn® . The CAP-e test directly measures antioxidant uptake and protection at the cellular level.
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Jobelyn® showed cellular antioxidant protection capacity in the CAP-e test. The cellular protection seen in the CAP-e assay allows us to conclude that Jobelyn® contains antioxidants that are bioavailable and functional at the cellular level. Protection was seen both in the water extract and in the ethanol extract. This suggests a complex range of biologically active antioxidants in Jobelyn®
IMMUNITY MODULATION
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WEST AFRICAN SORGHUM-BASED JOBELYN® HAS IMMUNE ACTIVATING PROPERTIES IN LABORATORY TESTS
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Jobelyn® is produced from a unique variety of Sorghum bicolor, recently domesticated from a West African wild variety, representing original genetic makeup and not a result of intense breeding efforts. Jobelyn® is an extract derived specifically from the intensely colored leaf sheathes. Sorghum is GRAS-certified by the FDA. Jobelyn® has an unusual chemical profile compared to other variants of Sorghum bicolor. It has a very high content of unique antioxidant polyphenols, including unique dimeric 3-deoxyanthocyanidins. Given the traditional use of Sorghum-based products, including teas, in prevention of viral illness, Jobelyn® was tested for immune activating properties in laboratory tests.
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Our immune system is not limited to a given organ or tissue, but is widespread throughout our body, blood, skin, and mucosal barriers. Immune cells, when activated, communicate in various ways by:
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Expressing receptors on cell surfaces to receive signals.
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Secreting compounds to send signals to other cells.​
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Jobelyn® treatment of human immune cells resulted in increased expression of the CD69 activation marker on the cell surface of Natural Killer cells, NKT cells, T lymphocytes, and monocytes. The cytokine profile in these cell cultures showed up-regulation of multiple cytokines, including several chemokines known to be involved in anti-viral immune defenses.
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